Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 2/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 10/20 | 0.38 |
| ▸ | BRAF | P15056 | 8/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | TEK | Q02763 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.34 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365264 | 0.81 | RHOA (0.38) | RAF1LCKJAK3TRPV4AAK1 | |
| SCHEMBL19706098 | 0.75 | RAF1 (0.36) | RAF1BRAFTRPV4 | |
| SCHEMBL16250015 | 0.73 | RHOA (0.38) | RAF1BRAFTRPV4 | |
| SCHEMBL16249950 | 0.72 | RHOA (0.40) | RAF1BRAFAAK1 | |
| SCHEMBL16775762 | 0.69 | RHOA (0.35) | RAF1BRAFAAK1 | |
| SCHEMBL16775776 | 0.68 | RHOA (0.36) | RAF1BRAFAAK1 | |
| SCHEMBL19365843 | 0.68 | RHOA (0.39) | BRAFLCK | |
| SCHEMBL19670289 | 0.67 | BRAF (0.42) | BRAFLCKKDRJAK3 | |
| SCHEMBL17618872 | 0.65 | RAF1 (0.35) | RAF1BRAFTRPV4 | |
| SCHEMBL16776431 | 0.65 | RHOA (0.32) | RAF1BRAFTRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014186313-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2014-11-20 | — | — | WO | disclosed |