Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | UBE2M | P61081 | 4/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365843 | 0.88 | RHOA (0.39) | RHOAPOLBRAB9AMCHR1UBE2M | |
| SCHEMBL19365806 | 0.83 | RHOA (0.42) | RHOAPOLBRAB9AMCHR1TRPV1 | |
| SCHEMBL19365586 | 0.81 | RHOA (0.38) | RHOAPOLBRAB9AMCHR1UBE2M | |
| SCHEMBL16249944 | 0.81 | SLC1A3 (0.39) | AAK1TRPV4RAF1LCKJAK3 | |
| SCHEMBL19365306 | 0.80 | POLB (0.44) | POLBRAB9AMCHR1UBE2MDCUN1D1 | |
| SCHEMBL19365784 | 0.78 | POLB (0.47) | POLBRAB9AMCHR1UBE2MDCUN1D1 | |
| SCHEMBL19365722 | 0.78 | POLB (0.41) | POLBRAB9AMCHR1UBE2MDCUN1D1 | |
| SCHEMBL19365636 | 0.78 | POLB (0.46) | POLBRAB9AMCHR1UBE2MDCUN1D1 | |
| SCHEMBL19706136 | 0.78 | RHOA (0.43) | RHOAPOLBRAB9AUBE2MDCUN1D1 | |
| SCHEMBL19670499 | 0.78 | RHOA (0.34) | RHOAPOLBRAB9AMCHR1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |