Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | RHOA | P61586 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670557 | 0.83 | PIK3CD (0.38) | FYNTP53MAPTMAPK1LCK | |
| SCHEMBL19365833 | 0.82 | RHOA (0.43) | BRAFRHOAFYNCASRTP53 | |
| SCHEMBL19706136 | 0.82 | RHOA (0.43) | BRAFRHOAFYNCASRTP53 | |
| SCHEMBL19670403 | 0.82 | BRAF (0.39) | BRAFRHOAFYNJAK3MAP4K4 | |
| SCHEMBL19365806 | 0.80 | RHOA (0.42) | BRAFRHOAFYNCASRLCK | |
| SCHEMBL19365489 | 0.79 | ALOX15 (0.48) | FYNMAP4K4LCKCA2CA9 | |
| SCHEMBL19365712 | 0.79 | RHOA (0.44) | BRAFRHOAFYNMAP4K4MAPT | |
| SCHEMBL19365619 | 0.77 | KMO (0.37) | BRAFRHOAMAP4K4CA2CA9 | |
| SCHEMBL19365558 | 0.76 | KDR (0.40) | BRAFRHOAFYNLCKPIK3CD | |
| SCHEMBL19365843 | 0.73 | RHOA (0.39) | BRAFRHOACASRLCKCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |