Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.39 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | NAMPT | P43490 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16252587 | 1.00 | KDM5A (0.39) | KDM5ACHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL16252580 | 1.00 | KDM5A (0.39) | KDM5ACHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL22916946 | 0.89 | CHRNB2 (0.50) | KDM5ACHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL16254569 | 0.83 | CA1 (0.41) | KDM5ACHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL15161291 | 0.83 | CA1 (0.41) | KDM5ACHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL16254560 | 0.83 | CA1 (0.41) | KDM5ACHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL21004139 | 0.83 | EPHX2 (0.41) | KDM5ACHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL10208258 | 0.82 | CHRNB2 (0.42) | KDM5ACHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL21003876 | 0.80 | KDM5A (0.40) | KDM5ACHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL23571255 | 0.79 | KDM5A (0.43) | KDM5ACHRNB2CHRNA3CHRNA4CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586956-B2 | Isoquinoline and naphthyridine derivatives | GENENTECH, INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-9586956-B2 | Isoquinoline and naphthyridine derivatives | GENENTECH, INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20140343036-A1 | ISOQUINOLINE AND NAPHTHYRIDINE DERIVATIVES | GENENTECH, INC. (US) | 2014-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343036-A1 | ISOQUINOLINE AND NAPHTHYRIDINE DERIVATIVES | NQO1, NDUFC2, NDUFV2 | KDM5A 2759/4885CHRNB2 2715/4885CHRNA3 2241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.