Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.72 |
| ▸ | VHL | P40337 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16207004 | 0.89 | EGFR (0.89) | EGFR | |
| SCHEMBL16258225 | 0.89 | EGFR (0.89) | EGFR | |
| SCHEMBL16196142 | 0.89 | EGFR (0.89) | EGFR | |
| SCHEMBL19107150 | 0.85 | EGFR (0.81) | EGFRVHLBTKJAK3 | |
| Naquotinib SCHEMBL16196078 | 0.84 | EGFR (1.00) | EGFR | |
| Naquotinib SCHEMBL29355759 | 0.84 | EGFR (1.00) | EGFR | |
| Naquotinib SCHEMBL19921009 | 0.84 | EGFR (1.00) | EGFR | |
| SCHEMBL21367012 | 0.82 | EGFR (0.80) | EGFRVHLBTKJAK3 | |
| Naquotinib SCHEMBL29409491 | 0.81 | EGFR (0.95) | EGFR | |
| Naquotinib SCHEMBL18687011 | 0.81 | EGFR (0.95) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805940-A1 | PYRAZINE CARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2014-11-26 | — | — | EP | disclosed |