Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CETP | P11597 | 7/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10196408 | 0.88 | LMNA (0.40) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL12424360 | 0.88 | LMNA (0.40) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL16258236 | 0.85 | LMNA (0.46) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL16258308 | 0.81 | CETP (0.52) | LMNAGAAHTTCETPADORA3 | |
| SCHEMBL12424359 | 0.78 | LMNA (0.44) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL10196400 | 0.78 | LMNA (0.44) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL664376 | 0.75 | CETP (0.39) | LMNACETPPKMALDH1A1KDM4E | |
| SCHEMBL12423364 | 0.74 | CETP (0.45) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL10196397 | 0.74 | CETP (0.45) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL12423601 | 0.73 | CETP (0.48) | LMNAGAAHTTCETPADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536733-B1 | TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION | BOEHRINGER INGELHEIM INT (DE) | 2014-11-26 | — | — | EP | disclosed |