Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 18/20 | 0.41 |
| ▸ | BRD2 | P25440 | 7/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 7/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16259130 | 0.74 | ERN1 (0.42) | BRD4BRD2BRD3ATAD2 | |
| SCHEMBL16259269 | 0.70 | ATAD2 (0.56) | BRD4BRD2ATAD2 | |
| SCHEMBL21253666 | 0.69 | BRD4 (0.39) | BRD4BRD2BRD3 | |
| SCHEMBL16140179 | 0.68 | BRD4 (0.64) | BRD4BRD2BRD3 | |
| SCHEMBL16259137 | 0.68 | BRD4 (0.57) | BRD4BRD2BRD3ATAD2 | |
| SCHEMBL16110281 | 0.68 | BRD4 (0.70) | BRD4BRD2BRD3 | |
| SCHEMBL23176959 | 0.66 | BRD4 (0.55) | BRD4BRD2BRD3LMNACYP1A2 | |
| SCHEMBL19013791 | 0.66 | BRD4 (0.48) | BRD4BRD2BRD3 | |
| SCHEMBL16259118 | 0.65 | BRD4 (0.44) | BRD4BRD2BRD3ATAD2 | |
| SCHEMBL21253762 | 0.65 | CYP1A2 (0.48) | BRD4BRD2BRD3LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014182929-A1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. (US) | 2014-11-13 | — | — | WO | disclosed |