Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 6/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5053642 | 0.85 | CYP19A1 (0.50) | CYP2D6CYP19A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL5049451 | 0.84 | CYP19A1 (0.54) | CYP2D6CYP19A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL18922484 | 0.82 | HSP90AA1 (0.63) | NPC1RAB9AHSP90AA1HSP90AB1MEN1 | |
| SCHEMBL28525427 | 0.79 | CYP19A1 (0.60) | CYP19A1L3MBTL1NPC1RAB9AATM | |
| SCHEMBL16263158 | 0.77 | MEN1 (0.50) | CYP19A1NPC1RAB9AHSP90AA1HSP90AB1 | |
| SCHEMBL16263156 | 0.75 | HSP90AA1 (0.63) | CYP19A1L3MBTL1NPC1RAB9AHSP90AA1 | |
| SCHEMBL16263153 | 0.75 | CYP19A1 (0.57) | CYP19A1NPC1RAB9AHSP90AA1HSP90AB1 | |
| SCHEMBL16263163 | 0.75 | ALOX5 (0.52) | CYP19A1L3MBTL1NPC1RAB9AHSP90AA1 | |
| SCHEMBL12251051 | 0.74 | CYP19A1 (0.60) | CYP19A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL5051923 | 0.74 | HDAC3 (0.64) | L3MBTL1NPC1RAB9AHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9771389-B2 | Tylosin derivatives and method for preparation thereof | THE KITASAKO INSTITUTE (JP) | 2017-09-26 | — | — | US | disclosed |
| US-9593140-B2 | Antibacterial tylosin derivatives and methods for their preparation | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-03-14 | — | — | US | disclosed |
| US-20160108077-A1 | TYLOSIN DERIVATIVES AND METHOD FOR PREPARATION THEREOF | THE KITASAKO INSTITUTE (JP) | 2016-04-21 | — | — | US | disclosed |
| US-20140349954-A1 | ANTIBACTERIAL TYLOSIN DERIVATIVES AND METHODS FOR THEIR PREPARATION | ELANCO ANIMAL HEALTH GMBH (DE) | 2014-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160108077-A1 | TYLOSIN DERIVATIVES AND METHOD FOR PREPARATION THEREOF | TMSB10, MLN, TMSB4X | CYP2D6 627/4885CYP19A1 2213/4885CYP2C9 436/4885 |
| US-20140349954-A1 | ANTIBACTERIAL TYLOSIN DERIVATIVES AND METHODS FOR THEIR PREPARATION | MLN, TMSB10, TMSB4X | CYP2D6 927/4885CYP19A1 2573/4885CYP2C9 867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.