Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16264515 | 0.81 | CYP2C9 (0.60) | MAPK8FLT3RAB9AMAPTNPC1 | |
| SCHEMBL2155229 | 0.75 | MAPK8 (0.70) | MAPK8FLT3RAB9AMAPTNPC1 | |
| SCHEMBL13789353 | 0.73 | MAPK8 (0.73) | MAPK8FLT3RAB9AMAPTNPC1 | |
| SCHEMBL1680689 | 0.71 | PTK2 (0.73) | MAPK8RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL446809 | 0.71 | GABRP (0.70) | MAPTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL24489080 | 0.70 | MAPK8 (0.59) | MAPK8FLT3RAB9AMAPTNPC1 | |
| SCHEMBL28679510 | 0.70 | MAPK8 (0.63) | MAPK8FLT3RAB9AMAPTNPC1 | |
| SCHEMBL16264394 | 0.70 | MAPK10 (0.57) | FLT3RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL11946878 | 0.70 | PTK2 (0.71) | MAPK8RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL13270043 | 0.70 | PTK2 (0.71) | MAPK8RAB9AMAPTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014190199-A1 | COMPOUNDS FOR TREATMENT OF DRUG RESISTANT AND PERSISTENT TUBERCULOSIS | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2014-11-27 | — | — | WO | disclosed |