Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18625972 | 0.87 | HDAC8 (0.58) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL19723300 | 0.85 | HDAC8 (0.53) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL19535082 | 0.84 | HDAC8 (0.62) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL18625958 | 0.83 | HDAC8 (0.51) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL16263157 | 0.83 | HDAC8 (0.51) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL18625973 | 0.82 | HDAC8 (0.48) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL9137418 | 0.81 | SRC (0.60) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL21286389 | 0.80 | HDAC8 (0.55) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL22868155 | 0.79 | HSP90AA1 (0.60) | CYP19A1SRCNPC1RAB9AATM | |
| SCHEMBL16264704 | 0.79 | CYP19A1 (0.62) | HDAC8HDAC6HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230255950-A1 | 3-(Hydroxy)-Pyridin-4(1H)-One Compounds and Methods of Making and Using the Same | GEORGIA TECH RESEARCH CORPORATION | 2023-08-17 | — | — | US | disclosed |
| EP-2999707-B1 | TYLOSIN DERIVATIVES AND METHOD FOR PREPARATION THEREOF | BAYER ANIMAL HEALTH GMBH (DE) | 2018-03-28 | — | — | EP | disclosed |
| EP-2782922-B1 | ANTIBACTERIAL TYLOSIN DERIVATIVES AND METHODS FOR THEIR PREPARATION | BAYER IP GMBH (DE) | 2017-12-20 | — | — | EP | disclosed |
| WO-2017190038-A1 | ANALOGS OF YOHIMBINE AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2017-11-02 | — | — | WO | disclosed |
| US-9771389-B2 | Tylosin derivatives and method for preparation thereof | THE KITASAKO INSTITUTE (JP) | 2017-09-26 | — | — | US | disclosed |
| US-9593140-B2 | Antibacterial tylosin derivatives and methods for their preparation | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-03-14 | — | — | US | disclosed |
| US-20160108077-A1 | TYLOSIN DERIVATIVES AND METHOD FOR PREPARATION THEREOF | THE KITASAKO INSTITUTE (JP) | 2016-04-21 | — | — | US | disclosed |
| US-20140349954-A1 | ANTIBACTERIAL TYLOSIN DERIVATIVES AND METHODS FOR THEIR PREPARATION | ELANCO ANIMAL HEALTH GMBH (DE) | 2014-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230255950-A1 | 3-(Hydroxy)-Pyridin-4(1H)-One Compounds and Methods of Making and Using the Same | KDM1B, KDM3A, KDM1A | HDAC8 194/4885HDAC6 2960/4885HDAC3 189/4885 |
| US-20160108077-A1 | TYLOSIN DERIVATIVES AND METHOD FOR PREPARATION THEREOF | TMSB10, MLN, TMSB4X | HDAC8 4011/4885HDAC6 1176/4885HDAC3 3025/4885 |
| US-20140349954-A1 | ANTIBACTERIAL TYLOSIN DERIVATIVES AND METHODS FOR THEIR PREPARATION | MLN, TMSB10, TMSB4X | HDAC8 4331/4885HDAC6 1147/4885HDAC3 3503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.