Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7624852 | 0.88 | IDO1 (0.47) | PNMTIDO1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL872658 | 0.87 | NPC1 (0.52) | SMN1; SMN2KDM4EKMT2AMEN1USP2 | |
| SCHEMBL29498164 | 0.87 | NPC1 (0.52) | SMN1; SMN2KDM4EKMT2AMEN1USP2 | |
| SCHEMBL16112452 | 0.86 | ALDH1A1 (0.46) | SMN1; SMN2KDM4EKMT2AUSP2LMNA | |
| SCHEMBL11267255 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2KDM4EKMT2AUSP2LMNA | |
| SCHEMBL17398610 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2KDM4EKMT2AUSP2LMNA | |
| SCHEMBL30296851 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2KDM4EKMT2AUSP2LMNA | |
| SCHEMBL11359843 | 0.84 | TAAR1 (0.49) | PNMTIDO1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5903219 | 0.84 | KDM4E (0.43) | SMN1; SMN2KDM4EKMT2AMEN1CYP2C9 | |
| SCHEMBL22969910 | 0.83 | KMT2A (0.46) | SMN1; SMN2KMT2AUSP2LMNATTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240300936-A1 | PREPARATION OF SUBSTITUTED 1,2-DIAMINOHETEROCYCLIC COMPOUND DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS | AVELOS THERAPEUTICS INC. (KR) | 2024-09-12 | — | — | US | disclosed |
| EP-4352049-A1 | PREPARATION OF SUBSTITUTED 1,2-DIAMINOHETEROCYCLIC COMPOUND DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS | Avelos Therapeutics Inc. (KR) | 2024-04-17 | — | — | EP | disclosed |
| CN-117529476-A | Preparation of substituted 1, 2-diamino heterocyclic derivatives and their use as medicaments | 亚飞络思制药公司 | 2024-02-06 | — | — | CN | disclosed |
| WO-2022260441-A1 | PREPARATION OF SUBSTITUTED 1,2-DIAMINOHETEROCYCLIC COMPOUND DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS | AVELOS THERAPEUTICS INC. (KR) | 2022-12-15 | — | — | WO | disclosed |
| EP-2061779-B1 | ARYL SULFONAMIDES WITH AN ANALGESIC ACTION | BOEHRINGER INGELHEIM INT (DE) | 2013-11-06 | — | — | EP | disclosed |
| US-7928139-B2 | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof | AMGEN INC. (US) | 2011-04-19 | — | — | US | disclosed |
| US-20100048572-A1 | NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | AMGEN INC. (US) | 2010-02-25 | — | — | US | disclosed |
| US-7635715-B2 | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof | AMGEN INC. (US) | 2009-12-22 | — | — | US | disclosed |
| EP-2111399-A2 | NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | Amgen Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| US-20090093483-A1 | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof | AMGEN INC. (US) | 2009-04-09 | — | — | US | disclosed |
| EP-0714917-A2 | Method of removing catalyst from ethylene-alpha-olefin copolymer | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1996-06-05 | — | — | EP | disclosed |
| EP-0651016-A1 | Polyphenylene ether thermoplastic resin composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1995-05-03 | — | — | EP | disclosed |
| EP-0346098-B1 | Copolymers of ethylene and an alpha-olefin and catalytic production thereof | SUMITOMO CHEMICAL CO (JP) | 1993-11-10 | — | — | EP | disclosed |
| US-5245007-A | Basification, oxidation | SUMITOMO CHEMICAL CO., LTD. (JP) | 1993-09-14 | — | — | US | disclosed |
| EP-0490672-A2 | Method of removing catalyst from ethylene-alpha-olefin copolymer | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1992-06-17 | — | — | EP | disclosed |
| US-5082908-A | Vanadium oxyhalide-aluminum-ester complex catalyst | SUMITOMO CHEMICAL CO., LTD. (JP) | 1992-01-21 | — | — | US | disclosed |
| EP-0346098-A2 | Copolymers of ethylene and an alpha-olefin and catalytic production thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1989-12-13 | — | — | EP | disclosed |
| EP-0044119-B1 | PROCESS FOR THE PREPARATION OF COPOLYMERS OF ETHYLENE WITH AT LEAST ONE OTHER 1-ALKENE | STAMICARBON B.V. (NL) | 1985-05-29 | — | — | EP | disclosed |
| US-4435552-A | COORDINATION CATALYST CONTAINING HALOACYL COMPOUND | STAMICARBON B.V. (NL) | 1984-03-06 | — | — | US | disclosed |
| EP-0044119-A2 | Process for the preparation of copolymers of ethylene with at least one other 1-alkene | STAMICARBON B.V. (NL) | 1982-01-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048572-A1 | NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | EGLN2, EGLN3, HIF1AN | PNMT 1403/4885IDO1 777/4885SMN1; SMN2 3976/4885 |
| US-20090093483-A1 | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof | EGLN2, EGLN3, HIF1AN | PNMT 1403/4885IDO1 777/4885SMN1; SMN2 3976/4885 |
| US-20240300936-A1 | PREPARATION OF SUBSTITUTED 1,2-DIAMINOHETEROCYCLIC COMPOUND DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS | MAST1, MAST3, MAST4 | PNMT 1574/4885IDO1 3658/4885SMN1; SMN2 1997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.