Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 1.00 |
| ▸ | USP2 | O75604 | 2/20 | 1.00 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.58 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.47 |
| ▸ | YAP1 | P46937 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1875327 | 0.89 | HSD17B10 (0.80) | HSD17B10USP2SIRT1RECQLSIRT2 | |
| SCHEMBL5445875 | 0.82 | HSD17B10 (0.69) | HSD17B10USP2SIRT1RECQLSIRT2 | |
| SCHEMBL29915361 | 0.73 | SIRT1 (1.00) | HSD17B10USP2SIRT1RECQLSIRT2 | |
| SCHEMBL8244015 | 0.73 | SIRT1 (1.00) | HSD17B10USP2SIRT1RECQLSIRT2 | |
| SCHEMBL29202845 | 0.72 | HSD17B10 (0.56) | HSD17B10USP2SIRT1SIRT2KDM4E | |
| SCHEMBL15451340 | 0.70 | SIRT1 (1.00) | HSD17B10USP2SIRT1RECQLSIRT2 | |
| SCHEMBL15278259 | 0.68 | MAPT (0.62) | HSD17B10USP2PAX8KDM4EGAA | |
| SCHEMBL15101429 | 0.68 | ALOX5 (0.67) | HSD17B10USP2KDM4EGAAMEN1 | |
| SCHEMBL20370864 | 0.68 | KDM4E (0.63) | HSD17B10USP2KDM4EGAAMEN1 | |
| SCHEMBL4160835 | 0.68 | KDM4E (1.00) | HSD17B10USP2RECQLPAX8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677794-B1 | METHODS OF TREATING DISORDER | ELIXIR PHARMACEUTICALS INC (US) | 2014-12-03 | — | — | EP | disclosed |