Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | PPID | Q08752 | 2/20 | 0.52 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ANPEP | P15144 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGAV | P06756 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2035741 | 0.91 | PPID (0.64) | ATML3MBTL1LCKPPIDNLRP3 | |
| SCHEMBL14617737 | 0.87 | ATM (0.62) | ATML3MBTL1LCKSMN1; SMN2ANPEP | |
| SCHEMBL14617704 | 0.86 | ATM (0.64) | ATML3MBTL1LCKPPIDSMN1; SMN2 | |
| SCHEMBL15832185 | 0.83 | PPID (0.65) | ATML3MBTL1LCKPPIDSMN1; SMN2 | |
| SCHEMBL14617754 | 0.83 | ATM (0.64) | ATML3MBTL1LCKPPIDSMN1; SMN2 | |
| SCHEMBL12643839 | 0.82 | ATM (0.65) | ATML3MBTL1LCKPPIDNLRP3 | |
| SCHEMBL2563776 | 0.82 | ATM (0.80) | ATML3MBTL1PPIDANPEPKLKB1 | |
| SCHEMBL14617757 | 0.80 | ATM (0.65) | ATML3MBTL1LCKSMN1; SMN2ANPEP | |
| SCHEMBL15832199 | 0.79 | ATM (0.57) | ATML3MBTL1LCKPPIDSMN1; SMN2 | |
| SCHEMBL14306569 | 0.78 | NLRP3 (0.49) | NLRP3POLBALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8901295-B2 | Inhibitors of cyclophilins and uses thereof | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2014-12-02 | — | — | US | disclosed |