Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | FPR3 | P25089 | 1/20 | 0.50 |
| ▸ | FPR2 | P25090 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12643847 | 0.88 | PPID (0.63) | CYP2D6KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL12993899 | 0.80 | KMT2A (0.64) | CYP3A4CYP2D6TSHRCYP2C19KMT2A | |
| SCHEMBL15832190 | 0.79 | PPID (0.73) | CYP3A4CYP2C19KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14679142 | 0.78 | HPGD (0.69) | CYP3A4CYP2D6TSHRCYP2C19KMT2A | |
| SCHEMBL15832157 | 0.78 | PPID (0.75) | KMT2AMEN1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL13102979 | 0.77 | HPGD (0.71) | CYP3A4CYP2D6TSHRCYP2C19KMT2A | |
| SCHEMBL23898822 | 0.76 | CA1 (0.62) | CYP3A4CYP2D6TSHRCYP2C19KMT2A | |
| SCHEMBL14617667 | 0.76 | SMN1; SMN2 (0.81) | CYP2C19KMT2AMEN1SMN1; SMN2GAA | |
| SCHEMBL14617672 | 0.75 | SMN1; SMN2 (0.70) | KMT2AMEN1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL13065455 | 0.75 | GAA (0.67) | CYP3A4CYP2D6TSHRCYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8901295-B2 | Inhibitors of cyclophilins and uses thereof | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2014-12-02 | — | — | US | disclosed |