Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | GAA | P10253 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.54 |
| ▸ | RELA | Q04206 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16273445 | 0.83 | MAPT (0.49) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL3337115 | 0.74 | GAA (0.64) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL12081693 | 0.74 | GAA (0.64) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL3337119 | 0.74 | GAA (0.64) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL16273441 | 0.73 | MEN1 (0.54) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL2553862 | 0.72 | MAPT (0.75) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL2553861 | 0.72 | MAPT (0.75) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL1822120 | 0.72 | MEN1 (1.00) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL12443462 | 0.71 | MEN1 (0.72) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL12081987 | 0.71 | MEN1 (0.59) | MEN1KMT2AMAPTGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9303024-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-20140357687-A1 | Pyrazol-3-ones That Activate Pro-apoptotic BAX | DANA FARBER CANCER INSTITUTE, INC. (US) | 2014-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357687-A1 | Pyrazol-3-ones That Activate Pro-apoptotic BAX | BAX, BAD, CASP3 | MEN1 4314/4885KMT2A 4718/4885MAPT 3506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.