Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16273447 | 0.79 | EGFR (0.53) | MEN1KMT2AGAALMNAALOX12 | |
| SCHEMBL22953101 | 0.78 | CA9 (0.44) | MEN1KMT2AGAALMNAALOX12 | |
| SCHEMBL22810959 | 0.77 | MEN1 (0.43) | MEN1KMT2AGAALMNAALOX12 | |
| SCHEMBL22811133 | 0.76 | PTGS2 (0.45) | MEN1KMT2AGAAMAPTALDH1A1 | |
| SCHEMBL12081776 | 0.75 | MEN1 (0.74) | MEN1KMT2AGAALMNAALOX12 | |
| SCHEMBL3335343 | 0.75 | MEN1 (0.74) | MEN1KMT2AGAALMNAALOX12 | |
| SCHEMBL3335339 | 0.75 | MEN1 (0.74) | MEN1KMT2AGAALMNAALOX12 | |
| SCHEMBL3406539 | 0.73 | ALOX5 (0.81) | MEN1KMT2AGAAMAPTALDH1A1 | |
| SCHEMBL29858889 | 0.73 | ALOX5 (0.81) | MEN1KMT2AGAAMAPTALDH1A1 | |
| SCHEMBL16273442 | 0.73 | MEN1 (0.54) | MEN1KMT2AGAALMNAALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9303024-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-20140357687-A1 | Pyrazol-3-ones That Activate Pro-apoptotic BAX | DANA FARBER CANCER INSTITUTE, INC. (US) | 2014-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357687-A1 | Pyrazol-3-ones That Activate Pro-apoptotic BAX | BAX, BAD, CASP3 | MEN1 4314/4885KMT2A 4718/4885GAA 1708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.