Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5439439 | 0.99 | EPHX2 (0.47) | EPHX2HRH3HRH2HRH1MAPK1 | |
| SCHEMBL5444759 | 0.95 | ACHE (0.48) | EPHX2HRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL5439478 | 0.84 | MAPT (0.45) | HRH3HRH2HRH1CYP1A2HTR2A | |
| SCHEMBL5194991 | 0.83 | MAPT (0.46) | HRH3CYP1A2HTR2A | |
| SCHEMBL5439520 | 0.83 | MAPT (0.46) | HRH3 | |
| SCHEMBL5439446 | 0.81 | MAPT (0.44) | HRH3ALDH1A1CYP1A2HTR2A | |
| SCHEMBL5438385 | 0.81 | MAPK14 (0.45) | HRH3ALDH1A1CYP1A2ACHEPSEN1 | |
| SCHEMBL5450888 | 0.81 | CCNC (0.41) | HRH3 | |
| SCHEMBL8264094 | 0.80 | MAPT (0.47) | HRH3ALDH1A1HTR2A | |
| SCHEMBL5445008 | 0.80 | MAPT (0.43) | HRH3ALDH1A1CYP1A2ACHEPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799646-B1 | NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2014-12-10 | — | — | EP | claimed |