Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.35 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16277463 | 0.92 | KEAP1 (0.40) | KDM4EHSD17B10GAAHPGDNOTUM | |
| SCHEMBL10597044 | 0.83 | KDM4E (0.45) | KDM4EHSD17B10GAAHPGDNOTUM | |
| SCHEMBL6827838 | 0.83 | KEAP1 (0.45) | KDM4ETTRALDH1A1IDO1MAP2K1 | |
| SCHEMBL3436916 | 0.83 | KDM4E (0.45) | KDM4EHSD17B10GAAHPGDNOTUM | |
| SCHEMBL24597721 | 0.81 | KDM4E (0.44) | KDM4EHSD17B10GAAHPGDNOTUM | |
| SCHEMBL19866316 | 0.81 | TP53 (0.41) | KDM4ETTRALDH1A1MAP2K1MAP2K2 | |
| SCHEMBL11948576 | 0.81 | KDM4E (0.44) | KDM4EHSD17B10GAAHPGDNOTUM | |
| SCHEMBL12931050 | 0.81 | KDM4E (0.44) | KDM4EHSD17B10GAAHPGDNOTUM | |
| SCHEMBL6119233 | 0.78 | GRM1 (0.51) | KDM4EHSD17B10GAAHPGDTTR | |
| SCHEMBL19399612 | 0.77 | KEAP1 (0.44) | KDM4EHSD17B10GAAHPGDNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180332-B1 | DIFLUOROPYRROLIDINES AS OREXIN RECEPTOR MODULATORS | EOLAS THERAPEUTICS INC (US) | 2021-10-27 | — | — | EP | disclosed |
| US-10221170-B2 | Difluoropyrrolidines as orexin receptor modulators | EOLAS THERAPEUTICS, INC. (US) | 2019-03-05 | — | — | US | disclosed |
| US-20170226103-A1 | DIFLUOROPYRROLIDINES AS OREXIN RECEPTOR MODULATORS | NIUVERA BIO, INC. | 2017-08-10 | — | — | US | disclosed |
| EP-3180332-A1 | DIFLUOROPYRROLIDINES AS OREXIN RECEPTOR MODULATORS | Eolas Therapeutics Inc. (US) | 2017-06-21 | — | — | EP | disclosed |
| US-9440982-B2 | Substituted prolines/piperidines as orexin receptor antagonists | EOLAS THERAPEUTICS, INC. (US) | 2016-09-13 | — | — | US | disclosed |
| WO-2016025669-A1 | DIFLUOROPYRROLIDINES AS OREXIN RECEPTOR MODULATORS | EOLAS THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |
| WO-2015123355-A1 | SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | EOLAS THERAPEUTICS, INC. (US) | 2015-08-20 | — | — | WO | disclosed |
| US-20140364433-A1 | SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364433-A1 | SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, OPRL1 | KDM4E 967/4885HSD17B10 1935/4885GAA 2148/4885 |
| US-10221170-B2 | Difluoropyrrolidines as orexin receptor modulators | HCRTR2, OPRD1, HCRTR1 | KDM4E 1535/4885HSD17B10 3417/4885GAA 1939/4885 |
| US-20170226103-A1 | DIFLUOROPYRROLIDINES AS OREXIN RECEPTOR MODULATORS | HCRTR2, OPRD1, HCRTR1 | KDM4E 1535/4885HSD17B10 3417/4885GAA 1939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.