Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTBP2 | P56545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Toluene SCHEMBL29217701 | 0.88 | L3MBTL1 (0.45) | CTBP2L3MBTL1HPGDTDP1KMT2A | |
| Toluene SCHEMBL4327028 | 0.85 | SMN1; SMN2 (0.44) | CTBP2RAB9AL3MBTL1HPGDTDP1 | |
| SCHEMBL5824805 | 0.82 | FFAR1 (0.50) | CTBP2RAB9AL3MBTL1NPC1TDP1 | |
| SCHEMBL105873 | 0.81 | MIF (0.48) | CTBP2RAB9ATDP1KMT2ASMN1; SMN2 | |
| SCHEMBL3574828 | 0.81 | CTBP2 (0.47) | CTBP2RAB9AL3MBTL1NPC1HPGD | |
| SCHEMBL5825140 | 0.81 | CES2 (0.39) | CTBP2ALDH1A1FFAR1 | |
| SCHEMBL371856 | 0.81 | CES1 (0.50) | CTBP2L3MBTL1HPGDKMT2AMEN1 | |
| SCHEMBL28414351 | 0.81 | HTT (0.53) | CTBP2NPC1TDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL13167103 | 0.79 | FFAR1 (0.36) | CTBP2KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL16896941 | 0.78 | TSHR (0.46) | RAB9AL3MBTL1NPC1HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8907091-B2 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | METHYLGENE INC. (CA) | 2014-12-09 | — | — | US | disclosed |