Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CASP1 | P29466 | 4/20 | 0.39 |
| ▸ | CASP7 | P55210 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15944165 | 0.82 | HCAR1 (0.44) | JAK2JAK1CYP1A2HSD17B10ALDH1A1 | |
| SCHEMBL4318007 | 0.77 | JAK1 (0.40) | JAK2JAK1CYP1A2HSD17B10ALDH1A1 | |
| SCHEMBL15833535 | 0.77 | CHEK2 (0.39) | JAK2JAK1CHEK2CHEK1AURKA | |
| SCHEMBL4168541 | 0.70 | TP53 (0.49) | JAK2JAK1MAPK14CLK4PRKCI | |
| Hydrochloric Acid SCHEMBL12539466 | 0.69 | CDK2 (0.42) | JAK2JAK1PIK3CAMTORPIK3CG | |
| SCHEMBL28234948 | 0.68 | ADORA2A (0.42) | JAK2JAK1HSD17B10ALDH1A1KMT2A | |
| SCHEMBL27438642 | 0.68 | PI4KA (0.42) | JAK2JAK1HSD17B10ALDH1A1KMT2A | |
| SCHEMBL14743315 | 0.68 | ADORA2A (0.49) | JAK2JAK1CYP1A2HSD17B10ALDH1A1 | |
| SCHEMBL15833600 | 0.68 | PRKCI (0.53) | JAK2JAK1HSD17B10MAPK14PRKCI | |
| SCHEMBL4373722 | 0.68 | SRC (0.40) | JAK2JAK1CYP1A2ALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906900-B2 | PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2014-12-09 | — | — | US | disclosed |