Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | PRKACA | P17612 | 2/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.39 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3290233 | 0.78 | DRD2 (0.57) | JAK2JAK1MAPK14MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL29398597 | 0.76 | DRD2 (0.56) | JAK2JAK1MAPK14MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL4919274 | 0.76 | DRD2 (0.56) | JAK2JAK1MAPK14MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL7655718 | 0.76 | DRD2 (0.56) | JAK2JAK1MAPK14MAPK13MAPK12 | |
| SCHEMBL30317222 | 0.75 | MAPK14 (0.41) | TP53JAK2JAK1MAPK14MAPK13 | |
| SCHEMBL30169464 | 0.73 | ACVR1 (0.52) | JAK2JAK1PRKCGCCR5HTR6 | |
| SCHEMBL8469729 | 0.73 | ACVR1 (0.52) | JAK2JAK1PRKCGCCR5HTR6 | |
| SCHEMBL1181760 | 0.73 | TP53 (0.50) | TP53CLK4CYP2C9HTR6 | |
| Hydrochloric Acid SCHEMBL4915661 | 0.72 | JAK1 (0.52) | JAK2JAK1MAPK14MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL29862952 | 0.72 | JAK1 (0.49) | JAK2JAK1MAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120232093-A1 | PYRAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-09-13 | — | — | US | disclosed |
| US-20120232093-A1 | PYRAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-09-13 | — | — | US | disclosed |
| US-20120232093-A1 | PYRAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-09-13 | — | — | US | disclosed |
| US-8202872-B2 | Pyrazole derivatives as sigma receptor inhibitors | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-06-19 | — | — | US | disclosed |
| US-8202872-B2 | Pyrazole derivatives as sigma receptor inhibitors | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-06-19 | — | — | US | disclosed |
| US-8202872-B2 | Pyrazole derivatives as sigma receptor inhibitors | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-06-19 | — | — | US | disclosed |
| US-20090264442-A1 | PYRAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVES, S.A. (ES) | 2009-10-22 | — | — | US | disclosed |
| US-20090264442-A1 | PYRAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVES, S.A. (ES) | 2009-10-22 | — | — | US | disclosed |
| US-20090264442-A1 | PYRAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVES, S.A. (ES) | 2009-10-22 | — | — | US | disclosed |
| US-20090069319-A1 | IMIDAZOPYRIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2009-03-12 | — | — | US | disclosed |
| EP-1994032-A1 | PYRAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | Laboratorios del Dr. Esteve S.A. (ES) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007098953-A1 | PYRAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-09-07 | — | — | WO | disclosed |
| EP-1829875-A1 | Pyrazole derivatives as sigma receptor inhibitors | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-09-05 | — | — | EP | disclosed |
| EP-1829875-A1 | Pyrazole derivatives as sigma receptor inhibitors | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-09-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069319-A1 | IMIDAZOPYRIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WNT1, CTNNB1, WNT3A | TP53 538/4885JAK2 453/4885JAK1 985/4885 |
| US-20090264442-A1 | PYRAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | SIGMAR1, TMEM97, OPRK1 | TP53 4654/4885JAK2 879/4885JAK1 564/4885 |
| US-20120232093-A1 | PYRAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | SIGMAR1, TMEM97, OPRK1 | TP53 4654/4885JAK2 879/4885JAK1 564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.