SCHEMBL1628355

SCHEMBL1628355

O=C1C=CC2=CN=NC2=N1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL367522 0.67
SCHEMBL600513 0.60 ALDH1A1 (0.32)
SCHEMBL14249193 0.53
SCHEMBL4065362 0.53
SCHEMBL13407 0.51
Methane SCHEMBL222390 0.48
SCHEMBL2221687 0.48
Methane SCHEMBL190374 0.48
SCHEMBL3754347 0.47
SCHEMBL4328507 0.47

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3994138-A1 ESTROGEN-RELATED RECEPTOR ALPHA (ERRalpha) MODULATORS Lead Pharma Holding B.V. (NL) 2022-05-11 EP claimed
WO-2021001453-A1 ESTROGEN-RELATED RECEPTOR ALPHA (ERRα) MODULATORS LEAD PHARMA HOLDING B.V. (NL) 2021-01-07 WO claimed
US-20110318345-A1 NASAL DELIVERY OPTINOSE AS (NO) 2011-12-29 US claimed
WO-2010029441-A2 NASAL DELIVERY OPTINOSE AS (NO) 2010-03-18 WO claimed
US-12409171-B2 Pharmaceutically active pyrazolo-pyridone modulators of DCN1/2-mediated cullin neddylation UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2025-09-09 US disclosed
EP-3994138-B1 ESTROGEN-RELATED RECEPTOR ALPHA (ERRALPHA) MODULATORS LEAD PHARMA HOLDING BV (NL) 2025-04-02 EP disclosed
EP-4045503-B1 ESTROGEN-RELATED RECEPTOR ALPHA (ERR-ALPHA) MODULATORS LEAD PHARMA HOLDING BV (NL) 2023-12-06 EP disclosed
CN-113149897-B 2, 6-substituted-4-oxyterpene phenolic pyridine compound and preparation method and application thereof 福建省中科生物股份有限公司 2023-10-31 CN disclosed
US-20230248925-A1 NASAL DELIVERY DEVICES Optinose, Inc. 2023-08-10 US disclosed
US-11602603-B2 Nasal delivery devices Optinose, Inc. (US) 2023-03-14 US disclosed
EP-4126225-A1 SMALL MOLECULES INDUCING THE DEGRADATION OF THE CELLULAR PRION PROTEIN Istituto Nazionale di Fisica Nucleare (IT) 2023-02-08 EP disclosed
US-20220280488-A1 PHARMACEUTICALLY ACTIVE PYRAZOLO-PYRIDONE MODULATORS OF DCN1/2-MEDIATED CULLIN NEDDYLATION UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2022-09-08 US disclosed
EP-1641454-A1 PYRAZOLO[3,4-B]PYRIDIN-6-ONES AS GSK-3 INHIBITORS Pfizer Products Inc. (US) 2006-04-05 EP disclosed
EP-1641455-A1 PYRAZOLO[3,4-B]PYRIDIN-6-ONES AS GSK-3 INHIBITORS Pfizer Products Inc. (US) 2006-04-05 EP disclosed
WO-2005016245-A2 COMPOUNDS HAVING INHIBITIVE ACTIVITY OF PHOSPHATIDYLINOSITOL 3-KINASE AND METHODS OF USE THEREOF ZENTARIS GMBH (DE) 2005-02-24 WO disclosed
US-20050026946-A1 GSK-3 inhibitors PFIZER INC 2005-02-03 US disclosed
WO-2005000304-A1 PYRAZOLO[3,4-B]PYRIDIN-6-ONES AS GSK-3 INHIBITORS PFIZER PRODUCTS INC. (US) 2005-01-06 WO disclosed
WO-2005000303-A1 PYRAZOLO`3,4-B!PYRIDIN-6-ONES AS GSK-3 INHIBITORS PFIZER PRODUCTS INC. (US) 2005-01-06 WO disclosed
US-20040266815-A1 Pyrazolo[3,4-b]pyridin-6-ones as GSK-3 inhibitors PFIZER INC 2004-12-30 US disclosed
US-20040266815-A1 Pyrazolo[3,4-b]pyridin-6-ones as GSK-3 inhibitors PFIZER INC 2004-12-30 US disclosed