Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GRM5 | P41594 | 10/20 | 0.45 |
| ▸ | DPP4 | P27487 | 4/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.43 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16285303 | 0.89 | NPC1 (0.59) | NPC1RAB9AGRM5DPP4DPP8 | |
| SCHEMBL2697700 | 0.86 | GRM5 (0.45) | NPC1RAB9AGRM5DPP4DPP8 | |
| SCHEMBL2699242 | 0.85 | GRM5 (0.53) | NPC1RAB9AGRM5DPP4DPP8 | |
| SCHEMBL16286087 | 0.82 | DPP4 (0.52) | NPC1RAB9AGRM5DPP4DPP8 | |
| SCHEMBL2700056 | 0.82 | RXFP1 (0.46) | NPC1RAB9AGRM5KDM4EALDH1A1 | |
| SCHEMBL20368922 | 0.81 | GRM5 (0.42) | NPC1RAB9AGRM5DPP4DPP8 | |
| SCHEMBL9964552 | 0.81 | GRAMD1A (0.44) | NPC1RAB9AGRM5DPP4DPP8 | |
| SCHEMBL12340949 | 0.81 | GRM5 (0.39) | NPC1RAB9AGRM5DPP4DPP8 | |
| SCHEMBL2699291 | 0.80 | GRAMD1A (0.53) | KDM4ESMN1; SMN2GRAMD1A | |
| SCHEMBL16286098 | 0.80 | NPC1 (0.51) | NPC1RAB9AGRM5DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9238658-B2 | Substituted piperidinyl-carboxamide derivatives useful as SCD 1 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2016-01-19 | — | — | US | disclosed |
| US-20140364393-A1 | SUBSTITUTED PIPERIDINYL-CARBOXAMIDE DERIVATIVES USEFUL AS SCD 1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364393-A1 | SUBSTITUTED PIPERIDINYL-CARBOXAMIDE DERIVATIVES USEFUL AS SCD 1 INHIBITORS | SCD, SCD5, FASN | NPC1 120/4885RAB9A 2991/4885GRM5 2827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.