Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 4/20 | 0.58 |
| ▸ | ACHE | P22303 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2092192 | 0.84 | NPC1 (0.63) | S1PR1ACHEMAPTTP53NPC1 | |
| SCHEMBL1233610 | 0.81 | ACHE (0.56) | S1PR1ACHEMAPTTP53NPC1 | |
| SCHEMBL27436286 | 0.79 | ACHE (0.64) | S1PR1ACHEMAPTTP53NPC1 | |
| SCHEMBL10120647 | 0.79 | NPC1 (0.66) | S1PR1ACHEMAPTTP53NPC1 | |
| SCHEMBL12112410 | 0.79 | ACHE (0.54) | S1PR1ACHEMAPTTP53NPC1 | |
| SCHEMBL30955218 | 0.79 | ACHE (0.64) | S1PR1ACHEMAPTTP53NPC1 | |
| SCHEMBL13415305 | 0.79 | ACHE (0.80) | ACHEMAPTTP53NPC1RAB9A | |
| SCHEMBL400963 | 0.78 | ACHE (0.67) | ACHEMAPTTP53NPC1RAB9A | |
| SCHEMBL18587629 | 0.78 | ESR1 (0.52) | S1PR1ACHEMAPTTP53PDK2 | |
| SCHEMBL28653849 | 0.77 | S1PR1 (0.63) | S1PR1TP53NPC1RAB9ANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968554-B2 | Pyrazolo[3,4-d]pyrimidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-06-28 | — | — | US | disclosed |
| US-7968554-B2 | Pyrazolo[3,4-d]pyrimidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-06-28 | — | — | US | disclosed |
| US-7968554-B2 | Pyrazolo[3,4-d]pyrimidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-06-28 | — | — | US | disclosed |
| EP-2188290-B1 | PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | HOFFMANN LA ROCHE (CH) | 2011-06-08 | — | — | EP | disclosed |
| US-7932390-B2 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-04-26 | — | — | US | disclosed |
| US-7932390-B2 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-04-26 | — | — | US | disclosed |
| US-7932390-B2 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-04-26 | — | — | US | disclosed |
| CN-101965349-A | Pyrazolo [3,4-D]-pyrimidine derivatives as antiproliferative | HOFFMANN LA ROCHE | 2011-02-02 | — | — | CN | disclosed |
| EP-2038288-B1 | NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENOÝ3,2¨PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-11-24 | — | — | EP | disclosed |
| EP-2038288-B1 | NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENOÝ3,2¨PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-11-24 | — | — | EP | disclosed |
| EP-2038288-A1 | NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENOÝ3,2¨PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| US-20090048274-A1 | PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES | BARTKOVITZ DAVID JOSEPH | 2009-02-19 | — | — | US | disclosed |
| US-20090048274-A1 | PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES | BARTKOVITZ DAVID JOSEPH | 2009-02-19 | — | — | US | disclosed |
| US-20090048274-A1 | PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES | BARTKOVITZ DAVID JOSEPH | 2009-02-19 | — | — | US | disclosed |
| WO-2009021869-A1 | PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-19 | — | — | WO | disclosed |
| US-20080009515-A1 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | CHEN YI | 2008-01-10 | — | — | US | disclosed |
| US-20080009515-A1 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | CHEN YI | 2008-01-10 | — | — | US | disclosed |
| US-20080009515-A1 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | CHEN YI | 2008-01-10 | — | — | US | disclosed |
| WO-2008000697-A1 | NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENO[3,2]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |
| WO-2008000697-A1 | NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENO[3,2]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048274-A1 | PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES | BRAF, RAF1, PRKDC | S1PR1 1279/4885ACHE 3935/4885MAPT 2018/4885 |
| US-20080009515-A1 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives | UQCRB, UQCRC2, AURKB | S1PR1 2684/4885ACHE 4636/4885MAPT 4268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.