Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCG | P01275 | 16/20 | 0.58 |
| ▸ | GCGR | P47871 | 4/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | GLP1R | P43220 | 1/20 | 0.37 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27922854 | 1.00 | GCG (0.58) | GCGGCGRCHRM5GLP1RCAPN1 | |
| SCHEMBL27942166 | 0.75 | GCG (0.79) | GCGGCGRCHRM5GLP1R | |
| SCHEMBL11899686 | 0.74 | GCG (1.00) | GCGGCGRCHRM5GLP1R | |
| SCHEMBL11900329 | 0.69 | GCGR (0.56) | GCGGCGRCHRM5GLP1R | |
| SCHEMBL11899422 | 0.65 | GCG (1.00) | GCGGCGRCHRM5GLP1R | |
| SCHEMBL11901780 | 0.63 | GCG (0.73) | GCGGCGR | |
| SCHEMBL11900233 | 0.63 | ESR2 (0.46) | GCG | |
| SCHEMBL11899950 | 0.62 | GCG (0.76) | GCGGCGR | |
| SCHEMBL11900878 | 0.60 | GCG (1.00) | GCGGCGR | |
| SCHEMBL27491579 | 0.60 | TSHR (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160362392-A1 | GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2016-12-15 | — | — | US | disclosed |
| EP-2673260-B1 | GLUCAGON RECEPTOR MODULATOR | PFIZER (US) | 2016-08-17 | — | — | EP | disclosed |
| US-9073871-B2 | Glucagon receptor modulators | PFIZER INC. (US) | 2015-07-07 | — | — | US | disclosed |
| US-20140371467-A1 | GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2014-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371467-A1 | GLUCAGON RECEPTOR MODULATORS | GLP1R, GCGR, GPR119 | GCG 15/4885GCGR 2/4885CHRM5 716/4885 |
| US-20160362392-A1 | GLUCAGON RECEPTOR MODULATORS | GLP1R, GCGR, GPR119 | GCG 15/4885GCGR 2/4885CHRM5 716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.