Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.60 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.60 |
| ▸ | AR | P10275 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 5/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1630789 | 0.88 | PGR (0.70) | PGRNR3C1NR3C2ARALDH1A1 | |
| SCHEMBL1629636 | 0.85 | PGR (0.66) | PGRNR3C1NR3C2ARALDH1A1 | |
| SCHEMBL1631091 | 0.84 | PGR (0.73) | PGRNR3C1NR3C2ARALDH1A1 | |
| SCHEMBL1630553 | 0.84 | PGR (0.64) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630207 | 0.82 | PGR (0.61) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630932 | 0.82 | PGR (0.65) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630776 | 0.81 | PGR (0.79) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1629716 | 0.81 | PGR (0.60) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1629963 | 0.81 | PGR (0.69) | PGRNR3C1NR3C2ARSCN9A | |
| SCHEMBL1629263 | 0.81 | PGR (0.57) | PGRNR3C1NR3C2ARBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979314-B1 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | LILLY CO ELI (US) | 2013-01-09 | — | — | EP | disclosed |
| US-7932284-B2 | Indole sulfonamide modulators of progesterone receptors | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |