Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.66 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.66 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.66 |
| ▸ | AR | P10275 | 6/20 | 0.66 |
| ▸ | BRD4 | O60885 | 8/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1631091 | 0.88 | PGR (0.73) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630553 | 0.88 | PGR (0.64) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630932 | 0.86 | PGR (0.65) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630207 | 0.86 | PGR (0.61) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1629716 | 0.85 | PGR (0.60) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1629326 | 0.85 | PGR (0.60) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630776 | 0.85 | PGR (0.79) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630908 | 0.83 | PGR (0.67) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1629263 | 0.82 | PGR (0.57) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1629264 | 0.82 | PGR (0.57) | PGRNR3C1NR3C2ARBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979314-B1 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | LILLY CO ELI (US) | 2013-01-09 | — | — | EP | disclosed |
| US-7932284-B2 | Indole sulfonamide modulators of progesterone receptors | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |