Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | CXCR4 | P61073 | 6/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16006904 | 0.84 | ACKR3 (0.39) | CHRM2CXCR4CYP3A4CYP2D6ACKR3 | |
| SCHEMBL28168442 | 0.82 | KDM5B (0.44) | CYP2D6KDM4EACKR3CYP1A2ALDH1A1 | |
| SCHEMBL16006933 | 0.81 | CXCR4 (0.37) | CHRM2CXCR4CYP3A4CYP2D6ACKR3 | |
| SCHEMBL16741961 | 0.76 | CHRM2 (0.92) | CHRM2CYP2D6KDM4ESCN8ACYP1A2 | |
| SCHEMBL4515742 | 0.75 | CHRM2 (0.55) | CHRM2CYP3A4KDM4ESCN8ACYP1A2 | |
| SCHEMBL16293260 | 0.74 | CHRM2 (0.71) | CHRM2KDM4ESCN8ASIRT2ALDH1A1 | |
| SCHEMBL16291869 | 0.74 | KDM5B (0.50) | KDM4EACKR3 | |
| SCHEMBL1879660 | 0.73 | CXCR4 (0.51) | CXCR4CYP3A4KDM4ECYP1A2ALDH1A1 | |
| SCHEMBL29823344 | 0.73 | CXCR4 (0.51) | CXCR4CYP3A4KDM4ECYP1A2ALDH1A1 | |
| SCHEMBL4067665 | 0.73 | CHRM2 (0.70) | CHRM2KDM4ESCN8ASIRT2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221801-B2 | Inhibitors of histone demethylases | EPITHERAPEUTICS APS (DK) | 2015-12-29 | — | — | US | disclosed |
| US-20140371214-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. | 2014-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371214-A1 | INHIBITORS OF HISTONE DEMETHYLASES | KDM1B, KDM1A, KDM3A | CHRM2 3004/4885CXCR4 4530/4885CYP3A4 2124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.