Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 11/20 | 0.50 |
| ▸ | KDM5A | P29375 | 6/20 | 0.43 |
| ▸ | KDM5C | P41229 | 6/20 | 0.43 |
| ▸ | KDM4A | O75164 | 3/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | KDM4B | O94953 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15636990 | 0.85 | KDM5B (0.60) | KDM5BKDM5AKDM5CKDM4AKDM4C | |
| SCHEMBL18708309 | 0.85 | KDM5B (0.57) | KDM5BKDM5AKDM5CKDM4AKDM4C | |
| SCHEMBL19574653 | 0.83 | KDM5B (0.70) | KDM5BKDM5AKDM5CKDM4AKDM4C | |
| SCHEMBL16291866 | 0.78 | KDM5B (0.44) | KDM5BKDM5AKDM5CKDM4AKDM4C | |
| SCHEMBL16006904 | 0.76 | ACKR3 (0.39) | KDM5BKDM5CKDM4AKDM4CACKR3 | |
| SCHEMBL16291896 | 0.76 | KDM5B (0.57) | KDM5BKDM5AKDM5CKDM4AKDM4C | |
| SCHEMBL16291759 | 0.74 | KDM5B (0.49) | KDM5BKDM5AKDM5CKDM4AKDM4C | |
| SCHEMBL16293306 | 0.74 | CHRM2 (0.55) | ACKR3KDM4E | |
| SCHEMBL15994092 | 0.73 | KDM5B (0.42) | KDM5BKDM5AKDM5CKDM4AKDM4C | |
| SCHEMBL28168442 | 0.72 | KDM5B (0.44) | KDM5BACKR3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10189787-B2 | Inhibitors of histone demethylases | GILEAD SCIENCES, INC. (US) | 2019-01-29 | — | — | US | disclosed |
| US-9611219-B2 | — | — | 2017-04-04 | — | — | US | disclosed |
| US-9611220-B2 | — | — | 2017-04-04 | — | — | US | disclosed |
| US-20150203453-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. | 2015-07-23 | — | — | US | disclosed |
| US-20140371195-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. | 2014-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10189787-B2 | Inhibitors of histone demethylases | EHMT1, KDM1B, EHMT2 | KDM5B 34/4885KDM5A 24/4885KDM5C 31/4885 |
| US-20150203453-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EHMT1, KDM1B, EHMT2 | KDM5B 34/4885KDM5A 25/4885KDM5C 31/4885 |
| US-20140371195-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EHMT1, KDM1B, EHMT2 | KDM5B 34/4885KDM5A 24/4885KDM5C 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.