Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15636990 | 0.88 | KDM5B (0.60) | KDM5BACKR3BCHEACHE | |
| SCHEMBL16293306 | 0.82 | CHRM2 (0.55) | ACKR3ALDH1A1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL19574653 | 0.77 | KDM5B (0.70) | KDM5BACKR3 | |
| SCHEMBL18708309 | 0.77 | KDM5B (0.57) | KDM5BACKR3 | |
| SCHEMBL7392031 | 0.75 | POLB (0.55) | KDM5BTAAR1POLBNPC1RAB9A | |
| SCHEMBL16291869 | 0.72 | KDM5B (0.50) | KDM5BACKR3KDM4E | |
| SCHEMBL19676466 | 0.70 | KDM5B (0.49) | KDM5B | |
| SCHEMBL16006904 | 0.70 | ACKR3 (0.39) | KDM5BACKR3CYP2D6SMN1; SMN2 | |
| SCHEMBL19574682 | 0.70 | KDM5B (0.49) | KDM5B | |
| SCHEMBL16294004 | 0.68 | ACKR3 (0.41) | KDM5BACKR3RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107434803-A | Histone demethylase inhibitor | 吉利德科学公司 | 2017-12-05 | — | — | CN | disclosed |
| CN-104981458-B | Inhibitors of histone demethylases | 吉利德科学公司 | 2017-07-21 | — | — | CN | disclosed |