Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13621171 | 0.82 | KDM4E (0.59) | KDM4EALDH1A1SMN1; SMN2L3MBTL1TSHR | |
| SCHEMBL13621178 | 0.81 | SMN1; SMN2 (0.56) | KDM4EALDH1A1SMN1; SMN2L3MBTL1ALOX15 | |
| SCHEMBL15994417 | 0.80 | KDM4E (0.43) | KDM4EHTTKDM1AMAOBL3MBTL1 | |
| SCHEMBL13621172 | 0.80 | ALDH1A1 (0.53) | KDM4EALDH1A1L3MBTL1POLBTDP1 | |
| SCHEMBL17364569 | 0.78 | KDM4E (0.42) | KDM4EHTTSMN1; SMN2KDM1AMAOB | |
| SCHEMBL13793636 | 0.76 | SMN1; SMN2 (0.56) | KDM4EHTTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL15995309 | 0.76 | KDM4E (0.40) | KDM4EHTTKDM1AMAOBMAOA | |
| SCHEMBL16303320 | 0.76 | KDM4E (0.40) | KDM4EHTTKDM1AMAOBMAOA | |
| SCHEMBL12831873 | 0.75 | SMN1; SMN2 (0.59) | KDM4EHTTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL29832698 | 0.75 | SMN1; SMN2 (0.62) | KDM4EHTTALDH1A1SMN1; SMN2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221801-B2 | Inhibitors of histone demethylases | EPITHERAPEUTICS APS (DK) | 2015-12-29 | — | — | US | disclosed |
| US-20140371214-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. | 2014-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371214-A1 | INHIBITORS OF HISTONE DEMETHYLASES | KDM1B, KDM1A, KDM3A | KDM4E 14/4885HTT 627/4885ALDH1A1 1536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.