Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 7/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15994417 | 0.91 | KDM4E (0.43) | KDM4EHTTGRM5KDM1AMAOB | |
| SCHEMBL16303320 | 0.83 | KDM4E (0.40) | KDM4EHTTGRM5KDM1AMAOB | |
| SCHEMBL15995309 | 0.83 | KDM4E (0.40) | KDM4EHTTGRM5KDM1AMAOB | |
| SCHEMBL16293797 | 0.78 | KDM4E (0.64) | KDM4EHTTKDM1AMAOBMAOA | |
| SCHEMBL17364567 | 0.71 | KDM5B (0.44) | KDM5B | |
| SCHEMBL16293304 | 0.70 | KMT2A (0.53) | KDM4EGAASMN1; SMN2RAB9A | |
| SCHEMBL15636442 | 0.70 | KDM5B (0.52) | KDM4EHTTKDM5B | |
| SCHEMBL16006937 | 0.69 | SIRT2 (0.36) | KDM4EKDM5B | |
| SCHEMBL16293110 | 0.69 | KDM2B (0.38) | — | |
| SCHEMBL15636702 | 0.69 | KDM5B (0.46) | KDM1AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221801-B2 | Inhibitors of histone demethylases | EPITHERAPEUTICS APS (DK) | 2015-12-29 | — | — | US | disclosed |