Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 10/20 | 0.84 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.84 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.84 |
| ▸ | AR | P10275 | 7/20 | 0.84 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14116609 | 1.00 | PGR (0.84) | PGRNR3C1NR3C2ARHSP90AA1 | |
| SCHEMBL1629568 | 1.00 | PGR (0.84) | PGRNR3C1NR3C2ARHSP90AA1 | |
| SCHEMBL1631200 | 0.92 | PGR (1.00) | PGRNR3C1NR3C2ARHSP90AA1 | |
| SCHEMBL1630450 | 0.88 | PGR (0.82) | PGRNR3C1NR3C2ARSCN9A | |
| SCHEMBL1630397 | 0.88 | PGR (0.75) | PGRNR3C1NR3C2ARSCN9A | |
| SCHEMBL1630750 | 0.88 | PGR (0.82) | PGRNR3C1NR3C2ARSCN9A | |
| SCHEMBL1630399 | 0.88 | PGR (0.75) | PGRNR3C1NR3C2ARSCN9A | |
| SCHEMBL1630401 | 0.88 | PGR (0.75) | PGRNR3C1NR3C2ARSCN9A | |
| SCHEMBL1630606 | 0.85 | PGR (1.00) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1629269 | 0.85 | PGR (1.00) | PGRNR3C1NR3C2ARBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979314-B1 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | LILLY CO ELI (US) | 2013-01-09 | — | — | EP | disclosed |
| US-7932284-B2 | Indole sulfonamide modulators of progesterone receptors | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |