Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.75 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.75 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.75 |
| ▸ | AR | P10275 | 6/20 | 0.75 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD1 | O95696 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1630397 | 1.00 | PGR (0.75) | PGRNR3C1NR3C2ARSCN5A | |
| SCHEMBL1630401 | 1.00 | PGR (0.75) | PGRNR3C1NR3C2ARSCN5A | |
| SCHEMBL1629438 | 0.91 | PGR (0.80) | PGRNR3C1NR3C2ARSCN5A | |
| SCHEMBL1630450 | 0.89 | PGR (0.82) | PGRNR3C1NR3C2ARSCN5A | |
| SCHEMBL1630750 | 0.89 | PGR (0.82) | PGRNR3C1NR3C2ARSCN5A | |
| SCHEMBL14116609 | 0.88 | PGR (0.84) | PGRNR3C1NR3C2ARSCN5A | |
| SCHEMBL1629568 | 0.88 | PGR (0.84) | PGRNR3C1NR3C2ARSCN5A | |
| SCHEMBL1629565 | 0.88 | PGR (0.84) | PGRNR3C1NR3C2ARSCN5A | |
| SCHEMBL14548891 | 0.86 | PGR (0.67) | PGRNR3C1NR3C2ARSCN5A | |
| SCHEMBL14116472 | 0.86 | PGR (0.67) | PGRNR3C1NR3C2ARSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979314-B1 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | LILLY CO ELI (US) | 2013-01-09 | — | — | EP | disclosed |
| US-7932284-B2 | Indole sulfonamide modulators of progesterone receptors | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |