Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 5/20 | 0.44 |
| ▸ | CA9 | Q16790 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 4/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11856721 | 0.84 | LMNA (0.59) | LMNACYP2C19ALDH1A1MAPK1THRB | |
| SCHEMBL11824133 | 0.83 | LMNA (0.55) | LMNACYP2C19ALDH1A1MAPK1THRB | |
| SCHEMBL4231086 | 0.82 | LMNA (0.57) | LMNACYP2C19ALDH1A1MAPK1THRB | |
| SCHEMBL11726262 | 0.82 | LMNA (0.57) | LMNACYP2C19ALDH1A1MAPK1THRB | |
| SCHEMBL1978635 | 0.82 | CYP2C19 (0.62) | LMNACYP2C19ALDH1A1MAPK1THRB | |
| SCHEMBL11638988 | 0.82 | LMNA (0.57) | LMNACYP2C19ALDH1A1MAPK1THRB | |
| SCHEMBL11826732 | 0.81 | LMNA (0.56) | LMNACYP2C19ALDH1A1MAPK1THRB | |
| SCHEMBL11828991 | 0.81 | LMNA (0.56) | LMNACYP2C19ALDH1A1MAPK1THRB | |
| Hydrochloric Acid SCHEMBL30884563 | 0.81 | LMNA (0.56) | LMNACYP2C19ALDH1A1MAPK1THRB | |
| SCHEMBL15752503 | 0.81 | LMNA (0.68) | LMNACYP2C19ALDH1A1MAPK1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928132-B2 | Methods for the amelioration of episodes of acute or chronic ulcerative colitis | OHIO UNIVERSITY (US) | 2011-04-19 | — | — | US | disclosed |
| US-4053482-A | 1-METHYL-2-(SUBSTITUTED THIOMETHYL)-5-NITRO-IMIDAZOLES | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-10-11 | — | — | US | disclosed |
| US-3984560-A | IMIDAZOLES | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-10-05 | — | — | US | disclosed |
| US-3962454-A | Bis-(1-alkyl-5-nitro-imidazolyl-2-alkyl)-compounds | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-06-08 | — | — | US | disclosed |