Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17396512 | 0.89 | TSHR (0.59) | HPGDGAAMAPK1TSHRALDH1A1 | |
| SCHEMBL640965 | 0.88 | HPGD (0.73) | HPGDL3MBTL1GAAMAPK1MEN1 | |
| SCHEMBL30392319 | 0.88 | HPGD (0.73) | HPGDL3MBTL1GAAMAPK1MEN1 | |
| SCHEMBL28459199 | 0.86 | HPGD (0.71) | HPGDL3MBTL1GAAMAPK1MEN1 | |
| SCHEMBL9266291 | 0.85 | HPGD (1.00) | HPGDL3MBTL1GAAMAPK1MEN1 | |
| SCHEMBL4912854 | 0.84 | HPGD (0.73) | HPGDL3MBTL1GAAMAPK1MEN1 | |
| SCHEMBL3149944 | 0.84 | L3MBTL1 (0.72) | HPGDL3MBTL1GAAMEN1KMT2A | |
| SCHEMBL8091743 | 0.82 | HPGD (0.60) | HPGDL3MBTL1GAAMAPK1MEN1 | |
| SCHEMBL39472 | 0.81 | HPGD (0.78) | HPGDL3MBTL1GAAMEN1KMT2A | |
| SCHEMBL16295605 | 0.80 | HPGD (0.47) | HPGDGAAMAPK1TSHRPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014199164-A1 | DIARYL SUBSTITUTED HETEROAROMATIC COMPOUNDS | AMPLA PHARMACEUTICALS, INC. (US) | 2014-12-18 | — | — | WO | disclosed |