Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9965425 | 0.81 | HPGD (0.69) | LMNAMAPTHPGDSMN1; SMN2MEN1 | |
| SCHEMBL30392319 | 0.80 | HPGD (0.73) | LMNAMAPTHPGDMEN1KMT2A | |
| SCHEMBL640965 | 0.80 | HPGD (0.73) | LMNAMAPTHPGDMEN1KMT2A | |
| SCHEMBL16294640 | 0.79 | SLC6A4 (0.49) | LMNAMAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL3039145 | 0.79 | HPGD (0.71) | LMNAMAPTHPGDSMN1; SMN2MEN1 | |
| SCHEMBL8012839 | 0.78 | TDP1 (0.60) | LMNAMAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL9266291 | 0.78 | HPGD (1.00) | LMNAMAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL3050533 | 0.78 | HPGD (0.69) | LMNAMAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL27830795 | 0.77 | HPSE (0.68) | LMNAMAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL6811413 | 0.77 | PARP1 (0.60) | LMNAMAPTHPGDPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014199164-A1 | DIARYL SUBSTITUTED HETEROAROMATIC COMPOUNDS | AMPLA PHARMACEUTICALS, INC. (US) | 2014-12-18 | — | — | WO | disclosed |