Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 2/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16312793 | 0.69 | PDE5A (0.55) | TSHRALDH1A1PDE5A | |
| SCHEMBL16298486 | 0.69 | PDE5A (0.52) | TSHRALDH1A1CYP11B2PDE5A | |
| SCHEMBL23974592 | 0.68 | TSHR (0.57) | TSHRALDH1A1CYP11B2ADORA2BSMN1; SMN2 | |
| SCHEMBL22105567 | 0.67 | TSHR (0.45) | TSHRALDH1A1CYP11B2ADORA2BSMN1; SMN2 | |
| SCHEMBL16298468 | 0.67 | PDE5A (0.62) | TSHRALDH1A1PDE5A | |
| SCHEMBL16298420 | 0.65 | TSHR (0.50) | TSHRALDH1A1CYP11B2PDE5ASMN1; SMN2 | |
| SCHEMBL233753 | 0.64 | TSHR (0.58) | TSHRALDH1A1CYP11B2PDE5AADORA2B | |
| SCHEMBL237742 | 0.63 | PDE5A (0.64) | PDE5A | |
| SCHEMBL193091 | 0.63 | PDE5A (0.67) | PDE5A | |
| SCHEMBL193092 | 0.63 | PDE5A (0.67) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003020724-A1 | POLYCYCLIC GUANINE PHOSPHODIESTERASE V INHIBITORS | SCHERING CORPORATION (US) | 2003-03-13 | — | — | WO | disclosed |