Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 14/20 | 0.75 |
| ▸ | CA2 | P00918 | 1/20 | 0.71 |
| ▸ | NCF1 | P14598 | 1/20 | 0.71 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MC4R | P32245 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4427871 | 0.93 | LMNA (0.67) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL16121577 | 0.86 | CHKA (1.00) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL19671018 | 0.84 | CHKA (0.77) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL13246320 | 0.84 | CHKA (0.77) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL12203050 | 0.84 | CHKA (0.77) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL2056181 | 0.84 | CHKA (0.77) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL18546870 | 0.84 | CHKA (0.77) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL12203051 | 0.84 | CHKA (0.77) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL1640969 | 0.83 | HRH3 (0.74) | NCF1KDM4EHRH3 | |
| SCHEMBL16095812 | 0.83 | CHKA (0.75) | CHKACA2NCF1PRMT6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-2298304-A2 | Carboline derivatives useful in the treatment of cancer | PTC Therapeutics, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |