Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 8/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | KIF11 | P52732 | 4/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16313346 | 0.93 | KIF11 (0.64) | TP53SMN1; SMN2LMNAKIF11ABCG2 | |
| SCHEMBL763430 | 0.88 | TP53 (0.61) | TP53SMN1; SMN2LMNAMAPTKIF11 | |
| SCHEMBL8402617 | 0.86 | TP53 (0.61) | TP53SMN1; SMN2LMNAMAPTKIF11 | |
| SCHEMBL764898 | 0.86 | TP53 (0.66) | TP53SMN1; SMN2LMNAMAPTKIF11 | |
| SCHEMBL16358492 | 0.86 | KIF11 (0.56) | TP53SMN1; SMN2LMNAKIF11ABCG2 | |
| SCHEMBL18689207 | 0.85 | LMNA (0.75) | TP53LMNAMAPTABCG2ABCB1 | |
| SCHEMBL13882354 | 0.84 | LMNA (0.73) | TP53LMNAMAPTABCG2ABCB1 | |
| SCHEMBL16299585 | 0.83 | KIF11 (0.63) | TP53SMN1; SMN2LMNAKIF11 | |
| SCHEMBL3344853 | 0.81 | TP53 (0.59) | TP53SMN1; SMN2LMNAMAPTKIF11 | |
| SCHEMBL3342885 | 0.81 | TP53 (0.59) | TP53SMN1; SMN2LMNAMAPTKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |