Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | LSS | P48449 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10086564 | 0.88 | KCNA5 (0.56) | DRD2HTR2ASIGMAR1LSSALDH1A1 | |
| SCHEMBL16314493 | 0.86 | DRD2 (0.51) | DRD2HTR2ASIGMAR1LSSALDH1A1 | |
| SCHEMBL16299414 | 0.80 | ALDH1A1 (0.65) | DRD2HTR2ASIGMAR1ALDH1A1POLB | |
| SCHEMBL13211936 | 0.79 | KCNA5 (0.59) | DRD2LSSALDH1A1POLBDRD3 | |
| SCHEMBL2965532 | 0.78 | ALDH1A1 (0.56) | LSSALDH1A1POLBMAPTMEN1 | |
| SCHEMBL16358258 | 0.78 | DRD3 (0.61) | DRD2DRD3MEN1KMT2A | |
| SCHEMBL6339805 | 0.78 | ALDH1A1 (0.52) | DRD2LSSALDH1A1POLBDRD3 | |
| SCHEMBL17888404 | 0.77 | DRD3 (0.59) | DRD2LSSALDH1A1POLBDRD3 | |
| SCHEMBL2235076 | 0.76 | POLB (0.69) | ALDH1A1POLBL3MBTL3MEN1KMT2A | |
| SCHEMBL17886732 | 0.76 | HPGD (0.65) | ALDH1A1POLBKDM4EMAPTCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2008127714-A1 | ADMINISTRATION OF CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |