Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 10/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16299595 | 0.92 | KIF11 (0.47) | KIF11MAPTKDM4ELMNAABCG2 | |
| SCHEMBL765030 | 0.88 | KIF11 (0.50) | KIF11MAPTKDM4ELMNAABCG2 | |
| SCHEMBL8404507 | 0.75 | KIF11 (0.47) | KIF11MAPTLMNAABCG2ABCB1 | |
| SCHEMBL16359562 | 0.75 | KIF11 (0.54) | KIF11MAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL8403171 | 0.75 | KIF11 (0.49) | KIF11MAPTKDM4ELMNAABCG2 | |
| SCHEMBL8403113 | 0.74 | ALDH1A1 (0.50) | KIF11MAPTKDM4ELMNAABCG2 | |
| SCHEMBL16313346 | 0.74 | KIF11 (0.64) | KIF11LMNAABCG2TP53SMN1; SMN2 | |
| SCHEMBL8403173 | 0.74 | KIF11 (0.49) | KIF11MAPTKDM4ELMNAABCG2 | |
| SCHEMBL3567366 | 0.74 | KIF11 (0.74) | KIF11MAPTLMNAABCG2 | |
| SCHEMBL16299551 | 0.74 | KIF11 (0.53) | KIF11MAPTLMNAABCG2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |