Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 10/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8403284 | 0.92 | KIF11 (0.56) | KIF11TP53MAPTSMN1; SMN2HTR2A | |
| SCHEMBL30757605 | 0.92 | KIF11 (0.56) | KIF11TP53MAPTSMN1; SMN2HTR2A | |
| SCHEMBL9962049 | 0.92 | KIF11 (0.56) | KIF11TP53MAPTSMN1; SMN2HTR2A | |
| SCHEMBL9962123 | 0.92 | KIF11 (0.56) | KIF11TP53MAPTSMN1; SMN2HTR2A | |
| SCHEMBL12978490 | 0.89 | TP53 (0.45) | KIF11TP53MAPTSMN1; SMN2ABCG2 | |
| SCHEMBL8403288 | 0.89 | TP53 (0.61) | KIF11TP53MAPTSMN1; SMN2HTR2A | |
| SCHEMBL11912892 | 0.89 | TP53 (0.60) | KIF11TP53MAPTSMN1; SMN2HTR2A | |
| SCHEMBL8403050 | 0.88 | ABCG2 (0.57) | KIF11TP53MAPTSMN1; SMN2ABCG2 | |
| SCHEMBL16299541 | 0.88 | TP53 (0.48) | KIF11TP53MAPTSMN1; SMN2ABCG2 | |
| SCHEMBL8403286 | 0.86 | TP53 (0.54) | KIF11TP53MAPTSMN1; SMN2ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |