Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 10/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9962023 | 0.93 | KIF11 (0.49) | TP53MAPTSMN1; SMN2KIF11SIRT1 | |
| SCHEMBL9962097 | 0.93 | KIF11 (0.49) | TP53MAPTSMN1; SMN2KIF11SIRT1 | |
| SCHEMBL16299541 | 0.92 | TP53 (0.48) | TP53MAPTSMN1; SMN2KIF11SIRT1 | |
| SCHEMBL9961992 | 0.91 | ABCG2 (0.51) | TP53MAPTSMN1; SMN2KIF11ABCG2 | |
| SCHEMBL13050120 | 0.90 | SIRT1 (0.49) | TP53MAPTSMN1; SMN2KIF11SIRT1 | |
| SCHEMBL9961995 | 0.90 | TP53 (0.55) | TP53MAPTSMN1; SMN2KIF11SIRT1 | |
| SCHEMBL9962022 | 0.90 | TP53 (0.56) | TP53MAPTSMN1; SMN2KIF11SIRT1 | |
| SCHEMBL16299549 | 0.89 | KIF11 (0.51) | TP53MAPTSMN1; SMN2KIF11SIRT1 | |
| SCHEMBL8403290 | 0.89 | KIF11 (0.50) | TP53MAPTSMN1; SMN2KIF11SIRT1 | |
| SCHEMBL13049027 | 0.88 | TP53 (0.47) | TP53MAPTSMN1; SMN2KIF11SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138695-A1 | METHODS FOR TREATING NEUROFIBROMATOSIS | PTC THERAPEUTICS, INC. (US) | 2010-12-02 | — | — | WO | disclosed |