Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 9/20 | 0.45 |
| ▸ | TP53 | P04637 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8403151 | 0.88 | KIF11 (0.51) | KIF11TP53MAPTKDM4EMEN1 | |
| SCHEMBL8403147 | 0.88 | KIF11 (0.49) | KIF11TP53MAPTLMNA | |
| SCHEMBL764960 | 0.80 | KIF11 (0.50) | KIF11TP53MAPTKDM4EMEN1 | |
| SCHEMBL763547 | 0.78 | KIF11 (0.57) | KIF11TP53MAPTMEN1KMT2A | |
| SCHEMBL11912840 | 0.77 | KIF11 (0.54) | KIF11TP53MAPTMEN1KMT2A | |
| SCHEMBL16314520 | 0.77 | LMNA (0.44) | KIF11TP53MAPTKDM4EMEN1 | |
| SCHEMBL764160 | 0.76 | KIF11 (0.49) | KIF11TP53MAPTKDM4EMEN1 | |
| SCHEMBL764697 | 0.76 | KIF11 (0.49) | KIF11TP53MAPTLMNA | |
| SCHEMBL8403135 | 0.76 | KIF11 (0.51) | KIF11TP53MAPTKDM4EMEN1 | |
| SCHEMBL8404381 | 0.76 | KIF11 (0.47) | KIF11TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |