Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.53 |
| ▸ | KIF11 | P52732 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404304 | 0.89 | TP53 (0.45) | LMNAKIF11TP53SMN1; SMN2MAPT | |
| SCHEMBL763841 | 0.88 | TP53 (0.45) | LMNAKIF11TP53SMN1; SMN2MAPT | |
| SCHEMBL763572 | 0.85 | TP53 (0.51) | LMNAKIF11TP53SMN1; SMN2MAPT | |
| SCHEMBL16313253 | 0.85 | TP53 (0.43) | KIF11TP53SMN1; SMN2MAPT | |
| SCHEMBL763780 | 0.84 | TP53 (0.42) | KIF11TP53SMN1; SMN2MAPT | |
| SCHEMBL8404214 | 0.83 | TP53 (0.46) | LMNAKIF11TP53SMN1; SMN2MAPT | |
| SCHEMBL16313317 | 0.83 | LMNA (0.59) | LMNAKIF11TP53SMN1; SMN2MAPT | |
| SCHEMBL763956 | 0.82 | TP53 (0.46) | LMNAKIF11TP53SMN1; SMN2MAPT | |
| SCHEMBL16359331 | 0.81 | LMNA (0.43) | LMNAKIF11TP53SMN1; SMN2MAPT | |
| SCHEMBL8404209 | 0.80 | TP53 (0.52) | LMNAKIF11TP53SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |