Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 8/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 3/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763841 | 0.90 | TP53 (0.45) | LMNATP53MAPTTHRBPOLB | |
| SCHEMBL763956 | 0.84 | TP53 (0.46) | LMNATP53MAPTTHRBPOLB | |
| SCHEMBL8404304 | 0.84 | TP53 (0.45) | LMNATP53MAPTSMN1; SMN2KIF11 | |
| SCHEMBL763780 | 0.83 | TP53 (0.42) | TP53MAPTSMN1; SMN2KIF11ABCG2 | |
| SCHEMBL763572 | 0.81 | TP53 (0.51) | LMNATP53MAPTSMN1; SMN2KIF11 | |
| SCHEMBL16299555 | 0.81 | LMNA (0.53) | LMNATP53MAPTSMN1; SMN2KIF11 | |
| SCHEMBL16359232 | 0.81 | TP53 (0.49) | LMNATP53MAPTTHRBPOLB | |
| SCHEMBL16313253 | 0.81 | TP53 (0.43) | TP53MAPTSMN1; SMN2KIF11ABCG2 | |
| SCHEMBL15086859 | 0.80 | TP53 (0.47) | LMNATP53MAPTTHRBPOLB | |
| SCHEMBL13696190 | 0.80 | TP53 (0.48) | LMNATP53MAPTTHRBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005089764-A9 | CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS | PTC THERAPEUTICS INC (US) | 2007-09-13 | — | — | WO | disclosed |