Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 3/20 | 0.40 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11959869 | 0.80 | IGF1R (0.50) | KCNH2IGF1RALOX15 | |
| SCHEMBL12474 | 0.79 | PYCR1 (0.50) | KCNH2 | |
| SCHEMBL14140405 | 0.78 | IGF1R (0.48) | KCNH2SLC6A2SLC6A4SLC6A3IGF1R | |
| SCHEMBL11959854 | 0.78 | IGF1R (0.48) | KCNH2SLC6A2SLC6A4SLC6A3IGF1R | |
| SCHEMBL12834984 | 0.78 | KCNH2 (0.61) | KCNH2FDPS | |
| SCHEMBL171910 | 0.78 | KCNH2 (0.50) | KCNH2IGF1RALOX15 | |
| SCHEMBL9280499 | 0.76 | SIGMAR1 (0.64) | KCNH2SIGMAR1IGF1RALOX15 | |
| SCHEMBL19493337 | 0.75 | SIGMAR1 (0.52) | KCNH2SIGMAR1 | |
| SCHEMBL22624601 | 0.75 | SIGMAR1 (0.61) | KCNH2SIGMAR1IGF1RALOX15FDPS | |
| SCHEMBL20231006 | 0.74 | KCNH2 (0.70) | KCNH2FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |