Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 10/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763761 | 0.90 | ABCG2 (0.49) | KIF11ABCG2MAPTTP53LMNA | |
| SCHEMBL16299590 | 0.87 | ABCG2 (0.48) | KIF11ABCG2MEN1KMT2ATP53 | |
| SCHEMBL763900 | 0.82 | ABCG2 (0.51) | KIF11ABCG2MEN1MAPTKMT2A | |
| SCHEMBL763656 | 0.81 | ABCG2 (0.51) | KIF11ABCG2TP53LMNAPOLB | |
| SCHEMBL16313346 | 0.81 | KIF11 (0.64) | KIF11ABCG2TP53SMN1; SMN2LMNA | |
| SCHEMBL764940 | 0.80 | ABCG2 (0.46) | KIF11ABCG2MEN1KMT2ATP53 | |
| SCHEMBL13727396 | 0.80 | KIF11 (0.50) | KIF11ABCG2MEN1MAPTKMT2A | |
| SCHEMBL763996 | 0.79 | ABCG2 (0.49) | KIF11ABCG2TP53LMNAPOLB | |
| SCHEMBL16299585 | 0.79 | KIF11 (0.63) | KIF11TP53SMN1; SMN2LMNA | |
| SCHEMBL16299515 | 0.77 | TP53 (0.60) | KIF11ABCG2MAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |