Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763647 | 0.89 | TP53 (0.47) | LMNAMAPTMEN1KMT2ATP53 | |
| SCHEMBL13725813 | 0.89 | LMNA (0.54) | LMNAMAPTMEN1KMT2ATP53 | |
| SCHEMBL10201944 | 0.86 | LMNA (0.54) | LMNAMAPTMEN1KMT2ATP53 | |
| SCHEMBL13727396 | 0.86 | KIF11 (0.50) | LMNAMAPTMEN1KMT2ATP53 | |
| SCHEMBL763503 | 0.85 | ESR1 (0.48) | LMNAMAPTMEN1KMT2ATP53 | |
| SCHEMBL763677 | 0.84 | LMNA (0.57) | LMNAMAPTMEN1KMT2ATP53 | |
| SCHEMBL11912410 | 0.84 | LMNA (0.46) | LMNAMAPTMEN1KMT2ATP53 | |
| SCHEMBL8403829 | 0.84 | ESR1 (0.53) | LMNAMAPTMEN1KMT2ATP53 | |
| SCHEMBL763582 | 0.84 | ESR1 (0.49) | LMNAMAPTMEN1KMT2ATP53 | |
| SCHEMBL763502 | 0.83 | ESR1 (0.52) | LMNAMAPTMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |